The chloroquine theory. Some real data, and an explanation of how and why it doesn’t work.
Thanks, Glenn for this.
Hopefully this takes some of air out of the hype machine:
368 patients evaluated (all of them male, all over age 65, all veterans because that's where the data came from):
In this study, we found no evidence that use of hydroxychloroquine, either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized with Covid-19. An association of increased overall mortality was identified in patients treated with hydroxychloroquine alone.
One interesting point this study does clarify; the original interest in chloroquine was because it is demonstrably effective in a petri dish; stops SARS-CoV-2 dead in its tracks. The difference is in a petri dish, they were getting concentrations of 4.5-17 µM, but the safe range in a human is around 1 µM. Trying to replicate the petri dish concentrations in living humans resulted in patients dying faster than COVID-19 would have killed them.